Effects of cortisol-awakening response on multi-target tracking in children with attention deficit hyperactivity disorder: the mediating role of working memory
10.3760/cma.j.cn371468-20231024-00174
- VernacularTitle:皮质醇觉醒反应对注意缺陷多动障碍儿童多目标追踪的影响：工作记忆的中介作用
- Author:
Qianyun LIU
1
;
Jianqun FANG
;
Shaoxia WANG
;
Xiang ZHANG
;
Ning MA
;
Manxue ZHANG
;
Yanrong WANG
Author Information
1. 宁夏医科大学临床医学院，银川 750001
- Keywords:
Attention deficit hyperactivity disorder;
Cortisol-awakening response;
Working memory;
Multiple object tracking;
Children
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(3):246-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mediating role of working memory (WM) in the cortisol-awakening response (CAR) and multiple object tracking (MOT) in children with attention deficit hyperactivity disorder (ADHD).Methods:92 children with ADHD (ADHD group) and 94 typically developing children (control group) were selected from January 2022 to October 2022. Salivary cortisol levels were detected and analyzed in all children at four time points after awakening. Children's WM and MOT performance were assessed by the 1-back and MOT paradigms, respectively. SPSS 26.0 software was used for t-test and Pearson correlation analysis of the data, and plug-in PROCESS model 4 of SPSS 26.0 was used for mediated effects analysis. Results:(1) ADHD group showed significantly lower CAR, 1-back accuracy and MOT performance((30.97±5.63), (81.33±10.64) %, (2.36±0.37)) than the control group((32.41±3.48), (91.19±7.12) %, (2.62±0.28))( t=-2.09, -7.22, -5.31, all P<0.05). (2) Pearson analysis showed that CAR was positively correlated with 1-back accuracy ( r=0.293, P<0.01) and MOT performance ( r=0.740, P<0.01). 1-back accuracy was positively correlated with MOT performance ( r=0.368, P<0.01). (3) WM partially mediated the effect of CAR on MOT in children with ADHD, accounting for 6.13% (0.003/0.049) of the total effect. Conclusion:Children with ADHD have deficits in MOT.WM plays a mediating role between CAR and MOT performance in children with ADHD.
