Research progress in reconsolidation-based interventions for aversive memories
10.3760/cma.j.cn371468-20230320-00133
- VernacularTitle:基于记忆再巩固的负性记忆干预研究进展
- Author:
Zhiying ZHENG
1
;
Yunfei ZHOU
;
Zhuo XIAO
;
Jingchu HU
Author Information
1. 深圳市精神卫生中心/深圳市康宁医院焦虑障碍科，深圳 518020
- Keywords:
Post-traumatic stress disorder;
Depression;
Phobic disorders;
Memory;
Psychological trauma
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(1):89-94
- CountryChina
- Language:Chinese
-
Abstract:
Aversive memories are the core pathology of many psychiatric disorders (such as posttraumatic stress disorder and depression), often impeding clinical treatment, which requires validated interventions. Animal researches and preclinical human studies have shown that memories are vulnerable after retrieval due to a memory process known as the memory reconsolidation mechanism, and that interventions during this process can potentially rewrite or update memories. The discovery of the reconsolidation mechanism has sparked a wave of research interest in its potential to rewrite aversive memories. This article presents a brief research history and advances in reconsolidation-based interventions, including pharmacological, non-invasive brain stimulation and behavioral interventions, as well as the biological mechanisms of reconsolidation. It is noted that pharmacological, behavioral and non-invasive brain stimulation interventions are all potential approaches for reconsolidation intervention, with propranolol, extinction/exposure therapy and transcranial magnetic stimulation being relatively effective. It is important to consider the differences between laboratory and clinical studies in future clinical translational research, and to overcome the " boundary conditions" of reconsolidation-based intervention in clinical applications, such as duration of memory retrieval, age of memory, individual differences, and so on, which may affect its efficacy.
