Progress in the neurobiology of post-traumatic stress disorder and depression comorbidity
10.3760/cma.j.cn371468-20230131-00043
- VernacularTitle:创伤后应激障碍共病抑郁的神经生物学研究进展
- Author:
Jiajie DAI
1
;
Mingyue ZHAO
;
Weiwen WANG
Author Information
1. 中国科学院心理研究所，中国科学院大学心理学系，北京 100101
- Keywords:
Trauma;
Post-traumatic stress disorder;
Depression;
Comorbidity;
Neurobiology
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2023;32(12):1135-1141
- CountryChina
- Language:Chinese
-
Abstract:
Traumatic events have lasting effects on mental and physical health, and significantly increase the incidence risk of psychiatric disorders. Post-traumatic stress disorder(PTSD) and depression are common psychopathological changes after traumatic stress. Studies have shown that the high comorbidity between PTSD and depression is the most common clinical complex syndrome after traumatic stress. This review systematically summarized PTSD and depression comorbidity studies from several aspects.In this paper, the clinical characteristics of PTSD and depression comorbidities were reviewed, suggesting that PTSD and depression comorbidities may have specific pathophysiological changes.Then the commonly used animal models of traumatic stress and the applications were introduced in the study of PTSD and depressive symptoms. Finally, clinical and basic research evidence of PTSD and depression comorbidity was outlined from several aspects, including brain circuit, neurotransmitter system, neuroendocrine, immune inflammation and neural plasticity, suggesting that PTSD and depressive symptoms comorbidity may have specific neurobiological basis.Existing studies support the need and importance to explore the pathological mechanisms of PTSD and depression comorbidities in depth and develop effective therapeutic targets for comorbidity.
