Role of frontal lobe and its related circuits involved in cognitive flexibility impairment in autism
10.3760/cma.j.cn371468-20221209-00745
- VernacularTitle:额叶及相关环路在孤独症认知灵活性损伤中的作用
- Author:
Chengming XU
1
;
Yalei FAN
;
Zhe ZHANG
;
Jiwei ZHANG
;
Liguo LI
;
Xianwen DONG
Author Information
1. 郑州大学第五附属医院康复医学重点实验室，郑州 450052
- Keywords:
Autism spectrum disorder;
Cognitive flexibility;
Frontal lobe;
Default mode network;
Neural circuit
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2023;32(11):1051-1056
- CountryChina
- Language:Chinese
-
Abstract:
Autism spectrum disorder (ASD) is a multifactorial disease, with social difficulties and repetitive behaviors as its core symptoms. With the improvement of diagnostic methods, the detection rate of ASD is increasing year by year.Cognitive flexibility impairment is very obvious in most autistic patients.More and more studies have shown that cognitive flexibility impairment is related to the occurrence and development of core symptoms. However, the mechanism of cognitive flexibility impairment in autism remains unclear. The frontal lobe plays an important role in advanced cognition, and its complete development is related to cognitive function. Recent studies have shown that frontal lobe dysfunction is closely related to cognitive flexibility deficits in autistic patients, and the abnormal changes in the frontal lobe, the associated default mode network dysfunction and frontal striatal circuit defects may be the important mechanisms of cognitive flexibility impairment. Based on the recent clinical and basic studies on cognitive flexibility in autism, this article reviews the mechanisms of frontal lobe and related circuits involved in the impairment of cognitive flexibility in autism.
