Role of the synaptic plasticity in chronic pain comorbidity anxiety disorder
10.3760/cma.j.cn371468-20221123-00708
- VernacularTitle:突触重塑在慢性疼痛共患焦虑障碍中的作用
- Author:
Yu WANG
1
;
Rui XU
;
Kun NI
;
Zhengliang MA
Author Information
1. 南京大学医学院附属鼓楼医院麻醉科，南京 210008
- Keywords:
Chronic pain;
Anxiety disorder;
Comorbidity;
Synaptic plasticity;
Neuron;
Neurotransmitter
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2023;32(10):951-955
- CountryChina
- Language:Chinese
-
Abstract:
Chronic pain patients are often accompanied with anxiety disorder, which promote the development of each other's disease process to a certain extent and seriously affect the quality of life of patients.However, the mechanism regulating the comorbidity between the two has not been clarified.Synaptic remodeling is the alteration of synaptic structure and function, which affects the transmission of signals between neurons.Synaptic remodeling is a hot topic in the field of chronic pain and anxiety disorders, but only few studies have explored its pathological changes in chronic pain and anxiety disorders.By summarizing the relevant researches in recent years, the occurrence of chronic pain co-anxiety disorder is closely related to changes in synaptic structure, synaptic transmission efficiency and synaptic function in brain regions.Synaptic remodeling could lead to the decline of centra pain regulation ability and aggravate the progression of chronic pain accompanied by anxiety disorder through ionic amino acid receptors, neuronal transmission and interactions between neurons and glial cells.Understanding the latest research progress of the co-morbidity mechanism of chronic pain and anxiety disorder is helpful to provide theoretical basis and potential new targets for its treatment.
