Prefrontal cortex activation in women with perimenopausal depression: a functional near-infrared spectroscopy study
10.3760/cma.j.cn371468-20230421-00194
- VernacularTitle:围绝经期抑郁女性前额叶皮质激活的近红外脑功能成像研究
- Author:
Cancan YU
1
;
Jiao SHI
;
Zhengxian XU
;
Xiaodong SONG
;
Ziyi WU
;
Xingchen ZHOU
;
Mengyang WANG
;
Dan WANG
;
Shangjie CHEN
;
Min WANG
Author Information
1. 蚌埠医学院第一附属医院康复医学科，蚌埠 233000
- Keywords:
Functional near-infrared spectroscopy;
Perimenopausal depression;
Emotion recognition;
Prefrontal cortex;
Brain region activation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2023;32(10):894-900
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relative concentration changes of oxygenated hemoglobin (Oxy Hb) in the prefrontal cortex (PFC) and brain region activation during emotional face recognition tasks in women with perimenopausal depression.Methods:From February to April 2023, forty perimenopausal women were recruited, including 20 women with perimenopausal depression (experimental group) and 20 women with non-perimenopausal depression (control group). All participants were evaluated by the modified Kupperman score, 24-item Hamilton depression scale (HAMD-24), and patient health questionnaire (PHQ-9). Functional near-infrared spectroscopy (fNIRS) equipment was used to measure the relative concentration of Oxy-Hb in the PFC in two groups under the emotional face recognition task. Statistical analysis was performed by SPSS 26.0 software. Data were analyzed by a t-test, rank sum test, and Pearson correlation. Results:There were statistically significant differences in the results of the modified Kupperman score((23.20±3.66), (18.10±1.28)), HAMD-24((15.95±5.47), (3.35±1.84)), and PHQ-9(7.00(5.00, 10.75), 1.50(1.00, 3.00)) scales between the the experimental group and control group ( P<0.05). There was a positive correlation between the modified Kupperman score and the HAMD-24 score in the experimental group ( r=0.685, P=0.01). The reaction time of the experimental group in identifying negative and neutral emotional faces was statistically significant compared to the control group( t=4.01, 4.80, both P<0.05). Compared with identifying neutral emotions, PFC activation was stronger in the experimental group and control group when identifying negative emotions ( P<0.05). The PFC activation in the experimental group was stronger than that in the control group when identifying negative emotions ( P<0.05). There was no statistically significant difference in the activation level between the two groups when identifying neutral emotions ( P>0.05). Conclusion:Women with perimenopausal depression exhibit specificity in emotional processing, with increased PFC activation when identifying negative emotions, impaired emotional processing function of PFC, and dysfunction of aerobic metabolism.
