The role of heat shock protein 70 in depression and its mechanisms
10.3760/cma.j.cn371468-20221117-00689
- VernacularTitle:热休克蛋白70在抑郁症中的作用及机制
- Author:
Chen LI
1
;
Ling XIAO
;
Yinping XIE
;
Lujia SI
;
Limin SUN
;
Guohao YUAN
;
Hailong GE
;
Gaohua WANG
Author Information
1. 武汉大学人民医院精神科，武汉 430060
- Keywords:
Depression;
Heat shock protein 70 (HSP70);
Oxidative stress;
Glucocorticoid receptor;
Neuroplasticity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2023;32(9):853-858
- CountryChina
- Language:Chinese
-
Abstract:
As a common psychiatric disorder, the etiology and pathogenesis of depression are complex and not yet fully elucidated.The diagnosis of depression mainly depends on the patients’ medical history, clinical symptoms and related examinations.Identification of biomarkers will provide important clues for the specific diagnosis and targeted treatment of depression.In addition to the widely recognized neurotransmitter dysregulation, hypothalamus-pituitary-adrenal axis hyperactivity, neuroplasticity, and neuro-inflammation theory, oxidative stress is also involved in the pathogenesis of depression in multiple ways.Many studies showed that the heat shock protein 70(HSP70)levels will increase in early stage to cope with the stress in patients with depression.However, lower HSP70 levels are often correlated with more severe depressive symptoms.HSP70 may be involved in depression through multiple pathways of oxidative stress, glucocorticoid receptors, neuroinflammation and neuroplasticity.Furthermore, increasing HSP70 expression results in significant improvement in depression-like behavior in animals.Thus, HSP70 possesses potential value as an early warning marker for depression as well as a therapeutic target.
