Correlation between serum GDNF level and neuroimaging changes and cognitive impairment in patients with cerebral small vessel disease
10.3760/cma.j.cn371468-20230207-00051
- VernacularTitle:脑小血管病患者血清GDNF水平与神经影像学改变、认知功能障碍的相关性
- Author:
Fangli YANG
1
;
Hao LIU
;
Fan WANG
;
Qing LI
;
Xiyan CHEN
;
Ruiyan CAI
;
Qingwu WU
;
Jian ZHANG
;
Sibei JI
;
Chengbiao LU
;
Shaomin LI
;
Jianhua ZHAO
Author Information
1. 新乡医学院第一附属医院神经内科，河南省神经修复重点实验室，河南省老年性痴呆神经修复国际联合实验室，新乡 453100
- Keywords:
Cerebral small vessel disease;
Glial cell-derived neurotrophic factor;
Cognitive impairment;
Magnetic resonance imaging;
Total image load
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2023;32(9):809-815
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between serum glial cell line-derived neurotrophic factor (GDNF) levels and neuroimaging changes and cognitive impairment in patients with cerebral small vascular disease (CSVD).Methods:135 patients with CSVD recruited from the Department of Neurology of the First Affiliated Hospital of Xinxiang Medical University from September 2021 to July 2022 were assessed by cranial multimodal magnetic resonance imaging and Montreal cognitive function assessment (MoCA), and the basic data were analyzed at the same time.The serum GDNF concentration of all patients was detected by enzyme-linked immunosorbent assay (ELISA). According to the median GDNF concentration, the patients were divided into low GDNF group and high GDNF group. The baseline data, MoCA score and imaging markers of the two groups were compared by Mann-Whitney U test, chi-square test, logistic regression, Kruskal-Wallis H test and Jonckheere-Terpstra trend test, and the correlation between serum GDNF level and imaging markers and cognitive function of patients with CSVD was analyzed. Results:The median serum GDNF concentration of all CSVD patients was 16.66 pg/mL. Multivariate logistic regression analysis showed that low serum GDNF level was a risk factor for white matter hyperintensity and total image load in patients with CSVD. Serum GDNF level was a protective factor of cognitive impairment in patients with CSVD in multiple logistic regression analysis. The area under the curve of ROC curve analysis of cognitive impairment after CSVD predicted by serum GDNF level was 0.735, the sensitivity was 66.4%, and the specificity was 71.4%. The level of serum GDNF was positively related with visual space and executive function, attention and computational power, delayed recall and orientation( r=0.267, 0.187, 0.219, 0.215, all P<0.05). Conclusion:The serum GDNF level is related to white matter hyperintensities, total imaging load and cognitive impairment in patients with CSVD. Serum GDNF level may play a predictive role in CSVD and cognitive impairment.
