Comparison of clinically relevant factors in bipolar disorder patients with different age of onset
10.3969/j.issn.1000-6729.2024.01.006
- VernacularTitle:不同发病年龄的双相障碍患者的临床表现
- Author:
Yan MA
1
;
Xiaoyi TIAN
;
Yueqin HUANG
;
Zhaorui LIU
;
Yongyan DENG
;
Liang ZHOU
;
Yan LIU
;
Bo LIU
;
Jie ZHANG
;
Yuandong GONG
;
Xiang FU
;
Qiongxian ZHAO
;
Jin LU
;
Wannian SHA
;
Hao HE
;
Zonglin SHEN
;
Tingting ZHANG
;
Wenming CHEN
Author Information
1. 普洱第二人民医院,云南普洱 665000
- Keywords:
bipolar disorder;
age of onset;
clinical characteristics;
physiological indicators;
treatment
- From:
Chinese Mental Health Journal
2024;38(1):42-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare clinical characteristics,treatment patterns and physiological indicators in bipolar disorder(BD)patients with different age of onset.Methods:Totally 380 patients with DSM-5 BD were se-lected in this study.Psychiatrists diagnosed the patients using the Mini International Neuropsychiatric Interview.The clinical information questionnaire and the Global Assessment of Functioning scale were utilized to collected clinical characteristics,treatment status,and physiological indicators.The onset age of BD was divided into 21 and 35 years as cut-off points.Multivariate logistic regression and linear regression were used to analyze related factors.Results:Among the 380 patients with BD,199 cases were early-onset group(52.4％),121 cases were middle-onset group(31.8％),and 60 cases were late-onset group(15.8％).There were 26.6％of patients in the early-onset group in-itially diagnosed as depression,23.1％in the middle-onset group,and 11.7％in the late-onset group.Multivariate analysis revealed that compared to the early-onset group of BD,the middle-onset(OR=2.22)and late-onset(OR=4.99)groups had more risk to experience depressive episodes,and the late-onset group(OR=6.74)had 6.74 times of risk to suffer from bipolar Ⅱ disorder.Additionally,patients in the middle-onset(β=-1.52)and late-on-set(β=-4.29)groups had shorter durations of delayed treatment,and those in the middle-onset(β=-1.62)and late-onset(β=-3.14)groups had fewer hospitalizations.Uric acid levels were lower in both the middle-onset(β=-28.39)and late-onset(β=-31.47)groups,and total cholesterol level was lower in the middle-onset group(β=-0.23).Conclusion:Patients with BD in different age of onset show significant differences in clinical charac-teristics,treatment conditions and physiological indicators.
