Comparison of clinical characteristics between first-episode and relapse of major depressive disorder
10.3969/j.issn.1000-6729.2024.01.004
- VernacularTitle:首发和复发抑郁症患者临床特征比较
- Author:
Xiuyan ZHENG
1
;
Chengxia TANG
;
Zhaorui LIU
;
Tingting ZHANG
;
Yueqin HUANG
;
Liang ZHOU
;
Yuandong GONG
;
Yan LIU
;
Bo LIU
;
Jie ZHANG
;
Haiming WANG
;
Zhengmin FENG
;
Jun GUO
;
Wenming CHEN
;
Linling JIANG
;
Defang CAI
;
Jin LU
Author Information
1. 云南省玉溪市第二人民医院,云南玉溪 653100
- Keywords:
major depressive disorder;
first-episode;
relapse;
clinical characteristics
- From:
Chinese Mental Health Journal
2024;38(1):25-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To describe demographic,clinical and physiological characteristics,treatment between first-episode major depressive disorder(MDD)and relapse MDD,and to explore characteristics of relapse MDD.Methods:Totally 858 patients who met the diagnostic criteria for depression of the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5),were included by using the Mini International Neuropsychiatric Interview(MINI),Clinician-Rated Dimensions of Psychosis Symptom Severity,and Hamilton Depression Scale etc.Among them,529(58.6％)were first-episode depression and 329(36.0％)were relapsed.The differences of demographic characteristics,clinical and physiological characteristics,treatment were compared byx2test and Kruskal-Wallis rank sum test.Multivariate logistic regression was used to explore the characteristics of MDD recur-rence.Results:Compared to first-episode MDD,relapse MDD had more comorbidity(OR=2.11,95％CI:1.00-4.44),more days out of role(OR=1.26,95％CI:1.01-1.56),more history of using psychiatric drug more than one month(OR=1.41,95％CI:1.02-1.97)and electroconvulsive therapy(OR=3.23,95％CI:1.42-7.36),and higher waist-hip ratio(OR=33.88,95％CI:2.88-399.32).Conclusion:Relapse MDD has positive as-sociation with comorbidity of mental disorders,out of role,and higher waist-hip ratio.
