Clinical characteristics and related factors of patients with schizophrenia in different ages of onset
10.3969/j.issn.1000-6729.2024.01.003
- VernacularTitle:不同首发年龄精神分裂症患者临床特征及影响因素
- Author:
Fan YANG
1
;
Peilin XU
;
Yueqin HUANG
;
Zhaorui LIU
;
Tingting ZHANG
;
Yanling HE
;
Jie ZHANG
;
Yuandong GONG
;
Yan LIU
;
Bo LIU
;
Lesheng ZHAO
;
Guoping WU
;
Min LIU
;
Yanjun WANG
;
Jicai WANG
;
Changqing GAO
;
Jin LU
Author Information
1. 昆明医科大学第一附属医院,昆明 650032
- Keywords:
schizophrenia;
age of onset;
Mini International Neuropsychiatric Interview;
Clinical-Rated Di-mensions of Psychosis Symptom Severity;
Positive and Negative Syndrome Scale
- From:
Chinese Mental Health Journal
2024;38(1):16-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical characteristics and related socio-demographic factors of schizo-phrenia patients with different ages of onset.Methods:Totally 2 016 patients with schizophrenia aged 15 to 70 were selected according to the diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition.All of the patients were interviewed by psychiatrists using the Mini International Neuropsy-chiatric Interview to diagnose schizophrenia,Clinical-Rated Dimensions of Psychosis Symptom Severity(CRDPSS)and the Positive and Negative Syndrome Scale(PANSS)to assess symptoms.The cut-off points were 18 and 25 years old for three age groups,i.e.early onset(EOS),youth onset(YOS)and adult onset(AOS).Statistical analy-ses were performed by analysis of variance Pearson correlation analysis,and multivariate linear regression.Results:The early-onset patients had the highest total PANSS score(73.8±28.0)and CRDPSS score(11.7±5.4).Fe-male gender,high education level,Han ethnicity,early onset age,and slower onset of illness were negatively corre-lated with the total and dimension score of PANSS scale and CRDPSS scale(standardized regression coefficient:0.04-0.47),and income level and smoking were negatively correlated with those score(standardized regression coefficient:-0.04--0.14).Conclusion:Early-onset schizophrenia patients have more severe symptoms,and fe-male,high education level,early-onset disease,and chronic onset are the risk factors of symptom severity in patients with schizophrenia.
