Impact of Baseline Non-high-density Lipoprotein Cholesterol Level on New-onset Cardiovascular Disease Among Postmenopausal Women
10.3969/j.issn.1000-3614.2024.01.008
- VernacularTitle:非高密度脂蛋白胆固醇对绝经后女性心血管疾病的影响
- Author:
Lisha ZHANG
1
,
2
;
Shouling WU
;
Zhiqiang SHAO
;
Jia GUO
;
Jian WANG
;
Wenqi XU
;
Lu GUO
;
Wenjuan LI
;
Shuohua CHEN
;
Yijun GAO
Author Information
1. 开滦总医院 妇产科,唐山 063000
2. 华北理工大学 研究生学院,唐山 063210
- Keywords:
postmenopausal women;
non-HDL-C level;
cardiovascular disease;
prospective cohort study
- From:
Chinese Circulation Journal
2024;39(1):61-67
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the impact of baseline non-high-density lipoprotein cholesterol(non-HDL-C)levels on new-onset cardiovascular disease(CVD)in postmenopausal women. Methods:This prospective cohort study selected 8 893 postmenopausal women who participated from 2006 to 2018 employee health examination of Kailuan Group and had complete total cholesterol(TC)and HDL-C data and no history of CVD.Participants were followed up to 31 December,2021.The primary endpoint was the occurrence of CVD or death.According to the Chinese Lipid Management Guidelines(2023),the participants were divided into non-HDL-C<4.1 mmol/L group(n=6 079),4.1 mmol/L≤non-HDL-C<4.9 mmol/L group(n=1 824)and non-HDL-C≥4.9 mmol/L group(n=990).The cumulative incidence of CVD in different groups of non-HDL-C levels was calculated using the Kaplan-Meier method and tested by log-rank analysis.Multivariate Cox regression model was used to analyze the effects of different non-HDL-C levels on CVD. Results:The mean follow-up time was(10.78±4.48)years,the cumulative incidence of CVD in different non-HDL-C level groups was 1.82%,3.24%and 2.89%,respectively.Kaplan-Meier survival curve showed a statistically significant difference in cumulative incidence among the three groups(log-rank P<0.0001).The results of Cox regression analysis showed that after adjusting for confounding factors such as age and sex,the HR(95%CI)values for CVD in the 4.1≤non-HDL-C<4.9 mmol/L group and the non-HDL-C≥4.9 mmol/L group were 1.40(1.13-1.74)and 1.35(1.03-1.78),respectively. Conclusions:High non-HDL-C levels are an independent risk factor for new-onset CVD in postmenopausal women.
