Analysis of the Impact of Different Low-density Lipoprotein Cholesterol Levels on the Progression of Intermediate Coronary Stenosis Based on Quantitative Flow Ratio Quantification
10.3969/j.issn.1000-3614.2024.01.007
- VernacularTitle:基于定量血流分数评估不同低密度脂蛋白胆固醇水平对冠状动脉临界病变的影响
- Author:
Qi CUI
1
;
Chuanqi ZHANG
;
Xiaopeng YUAN
;
Xiao WANG
;
Naqiang LYU
;
Shuang LI
;
Pengzhao GUO
;
Jing ZHANG
;
Chuanyu GAO
;
Aimin DANG
Author Information
1. 郑州大学 阜外华中心血管病医院 心内科,郑州 451464
- Keywords:
low-density lipoprotein cholesterol;
quantitative flow ratio;
intermediate coronary stenosis;
coronary atherosclerotic heart disease
- From:
Chinese Circulation Journal
2024;39(1):54-60
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:This study aims to investigate the impact of different Low-Density Lipoprotein cholesterol(LDL-C)levels on progression of intermediate coronary stenosis,and the associated risk factors leading to the progression of such lesions. Methods:Data were collected on 219 consecutive patients admitted at the Fuwai Central China Vascular Hospital from January 2020 to February 2021,underwent angiographic examinations and diagnosed with intermediate coronary stenosis,with at least one follow-up angiography after 11 months.Offline quantitative flow ratio(QFR)analysis was performed on these cases.Patients were divided into two groups:LDL-C controlled group(LDL-C<1.8 mmol/L,148 patients with 191 vessels)and LDL-C uncontrolled group(LDL-C≥1.8 mmol/L,71 patients with 98 vessels).Coronary artery QFR and anatomical indicators such as minimal lumen diameter,minimal lumen area,percentage diameter stenosis,percentage area stenosis were compared within and between the groups.Further analysis was performed to identify influencing factors leading to changes in coronary physiological parameters derived from QFR. Results:Within the LDL-C controlled group,there was no significant difference in the QFR values of the vessels compared to baseline(P>0.05),whereas in the LDL-C uncontrolled group(P<0.05),a notable decline in QFR was observed.Patients in the LDL-C controlled group had lower rates of maximum diameter and area stenosis and higher minimum lumen diameter and area(all P<0.05).Through multifactorial Logistic regression analysis,it was found that a body mass index＞28 kg/m2,LDL-C≥1.8 mmol/L,and a history of myocardial infarction were independent risk factors leading to the decline in QFR(all P<0.05). Conclusions:It was found that patients in the LDL-C controlled group had higher coronary artery QFR,minimum lumen diameter and area,lower rates of maximum diameter and area stenosis.
