Effect and Potential Mechanism of Resistance Exercise on the Dissolution of Catheter-associated Thrombus
10.3969/j.issn.1000-3614.2023.12.010
- VernacularTitle:抗阻运动调控鸢尾素促进导管相关性血栓溶解再通的研究
- Author:
Xiaoyan LI
1
;
Yanping YING
;
Jia'ao XU
;
Caijiao WU
;
Jiani WEI
;
Huihan ZHAO
Author Information
1. 广西医科大学第一附属医院 护理部,南宁 530021
- Keywords:
catheter-associated thrombus;
resistance movement;
dissolve and recanalize;
irisin
- From:
Chinese Circulation Journal
2023;38(12):1291-1296
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the effect of resistance exercise(RE)on the dissolution of catheter-associated thrombus(CRT)and its possible mechanism.Methods:A total of 36 male SD rats were randomly divided into control group,CRT group,CRT+ RE group(n=12 in each group).Rats in the CRT group did not receive any intervention,while rats in the CRT+RE group received RE intervention 10 days after modeling for 28 days.The thrombolysis rate was evaluated by Hematoxylin-Eosin staining.The contents of irisin,interleukin(IL)-6 and IL-10 in serum were detected by ELISA.The relative mRNA expression levels of peroxisome proliferator-activated receptor γ coactivator α(PGC-1α)and fibronectin type Ⅲ domain-containing 5(FNDC5)in gastrocnemius were detected by real-time quantitative PCR(qPCR).Results:There was no thrombosis in control group.Compared with control group,the contents of irisin and IL-10 in CRT group were significantly decreased,while the content of IL-6 in CRT rats was significantly increased(all P<0.01).Thrombolysis rate was significantly higher,and the mRNA expressions of PGC-1α and FNDC5 in gastrocnemius were significantly upregulated in CRT+RE group than in CRT group(all P<0.01).Serum irisin,IL-10 contents were significantly increased,IL-6 content was significantly lower in CRT+RE group than in CRT group(all P<0.01).Conclusions:Resistance exercise for 28 days could promote the dissolution of CRT,which may be related to the up-regulation of irisin expression and the inhibition of inflammation.
