Investigation on Coronavirus Disease-2019,Clinical Characteristics and Influencing Factors in Patients With Pulmonary Hypertension During the Coronavirus Disease-2019 Pandemic
10.3969/j.issn.1000-3614.2023.12.009
- VernacularTitle:新型冠状病毒大流行期间肺动脉高压患者的新型冠状病毒感染情况及危险因素分析
- Author:
Anqi DUAN
1
;
Yi ZHANG
;
Zhihui ZHAO
;
Qing ZHAO
;
Xin LI
;
Zhihua HUANG
;
Meixi HU
;
Sicheng ZHANG
;
Luyang GAO
;
Qin LUO
;
Zhihong LIU
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 呼吸和肺血管疾病中心,北京 100037
- Keywords:
pulmonary hypertension;
coronavirus disease-2019;
vaccine;
heart failure
- From:
Chinese Circulation Journal
2023;38(12):1285-1290
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the prevalence,clinical characteristics and risk factors of coronavirus disease-2019(COVID-19)in patients with pulmonary hypertension(PH). Methods:A questionnaire survey was conducted from December 30,2022 to January 6,2023 through the WeChat official account of the PH Patients Mutual Aid Organization.PH patients aged≥18 years from 26 province(municipality/autonomous region)were recruited to fill in the electronic survey questionnaire. Results:A total of 293 valid questionnaires were collected from PH patients.The mean age of patients was(40.6±12.7)years,and 226 patients(77.1%)of them were female.The vaccination rate was 59.7%(175/293),117 patients(39.9%)received three or more doses of vaccine,145 patients(49.5%)received inactivated vaccine.242 patients(82.6%)had COVID-19.The most common symptoms during infection were fever(85.5%),cough(77.7%),and fatigue(66.5%).10.7%of the patients had severe or critical COVID-19.Age(OR =1.057,95%CI:1.027-1.087,P<0.001)and comorbid pulmonary disease(OR=3.341,95%CI:1.215-9.184,P=0.019)were associated with severe or critical COVID-19.After adjusting for confounding factors,age was an independent risk factor for severe or critical COVID-19(OR=1.049,95%CI:1.019-1.080,P=0.001).Severe or critical COVID-19 was an independent risk factor for worsening heart failure in PH patients during COVID-19 pandemic(OR=10.522,95%CI:4.311-25.682,P<0.001). Conclusions:The immunization coverage of PH patients is insufficient.PH patients have a higher risk of developing severe or critical COVID-19 than general population.Ageing is an independent risk factor for severe or critical COVID-19,and the risk of worsening heart failure in PH patients with severe or critical COVID-19 is significantly increased during COVID-19 pandemic.
