Protein expression and clinical significance of KCTD8 gene in ductal carcinoma of the breast
10.3969/j.issn.1009-9905.2024.02.006
- VernacularTitle:KCTD8基因在乳腺导管内癌中的蛋白表达及临床意义
- Author:
Ying-Ge LIU
1
;
Hui-Jie YANG
;
Xiao-Yu ZHAI
;
Ji-Min HE
;
Hong-Chao LI
;
Ying-Li ZHANG
Author Information
1. 河南省濮阳市油田总医院 病理科(河南 濮阳 457001)
- Keywords:
Breast cancer;
Ductal carcinoma in situ;
KCTD8;
Immunohistochemistry technology
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(2):117-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of KCTD8 gene in breast ductal carcinoma and its correlation with clinical factors and prognosis.Methods:Immunohistochemistry technology(IHC)were employed to detect protein expression levels of KCTD8 in 27 pairs of breast ductal carci-noma and its paired adjacent tissues.Analyzing the correlation between changes in KCTD8 expres-sion of protein and clinical factors using statistical techniques.RNA expression and methylation data of breast cancer(including intraductal cancer)were analysed from TCGA database.Result:The pro-tein expression of KCTD8 gene in 27 pairs of breast ductal carcinoma tissues showed a decreasing trend compared to adjacent tissues(P＜0.05),and the decreased expression level of protein was cor-related with the tumor size of patients(P＜0.05).The analysis results of the TCGA database indicate that the expression and hypemethylation of KCTD 8 gene in breast cancer(including intraductal can-cer)tissues affected the prognosis of patients.Conclusion:The reduced protein expression level of KCTD8 gene in breast ductal carcinoma may be involved in the development and affect the prog-nosis of patients.
