Pyroptosis-related genes defines the progression and im-mune tolerance microenvironment of hepatocellular carcino-ma
10.3969/j.issn.1009-9905.2024.02.003
- VernacularTitle:细胞焦亡相关基因与肝细胞癌进展及预后关系的生物信息学分析
- Author:
Xiao-Dong HAO
1
;
Yi-Dan REN
;
Mao-Xiao FENG
;
Yun-Shan WANG
Author Information
1. 山东大学第二医院 检验科(山东 济南 250033)
- Keywords:
Hepatocellular carcinoma;
Pyroptosis-related genes;
Prognosis;
Bioinformatics
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(2):98-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression pattern of pyroptosis-related genes(PRGs)in hepatocellular carcinoma(HCC),and analyze the relationship between its expression and tumor prog-nosis and immune microenvironment.Methods:TCGA database was used to analyze the genetic changes and expression patterns of PRGs in primary HCC cells,and cluster analysis was used to i-dentify the pyrogenic subtypes of HCC.To compare the difference of prognosis and immune mi-croenvironment among HCC pyrodeath subtypes.Scorch death score quantified the comprehensive expression of PRGs in each sample,and analyzed the correlation between scorch death score and each immune score.Results:Two pyroptosis-associated subtypes of primary HCC were identi-fied,and the expression pattern of PRGs is closely related to the prognosis of cancer patients and the tumor microenvironment.The subtype with high expression of PRGs had a poor prognosis,and functional enrichment analysis found that some tumor-promoting pathways and PD-1 checkpoint pathways were significantly enriched in this subtype.And various cells and immune checkpoints re-lated to immunosuppression were also enriched in this subtype.By constructing PYROPTO-SIS_score to quantify the comprehensive expression of pyroptosis-related genes in each sample,it was found that PYROPTOSIS_score was significantly positively correlated with tumor-infiltrating macrophages,myeloid-derived suppressor cells,and Treg cells.Conclusion:These results sug-gest that pyroptosis may play a tumor-promoting as well as immunosuppressive role in HCC,pro-viding new insights into the assessment of tumor patient prognosis and the immune microenviron-ment.
