Clinical safety and validity analysis of retrograde new endo-scopic visual field in miniature pigs
10.3969/j.issn.1009-9905.2024.01.003
- VernacularTitle:小型猪实验验证内镜逆行新视野的临床安全性及有效性
- Author:
Zhe KUANG
1
;
Peng LI
;
Da-Qing JIN
;
Yong-Chao ZHANG
;
Hui-Li GUO
;
Yu-Fei ZHANG
;
Guang-Lin HE
;
Guo-Feng SUN
;
Yuan HE
Author Information
1. 首都医科大学附属北京友谊医院 消化内科(北京 100050)
- Keywords:
Animal experiment;
Endoscope;
Security;
Validity;
Pig
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(1):14-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical safety and validity of retrograde new endoscopic field of vision in miniature pigs.Methods:6 live miniature pigs were selected as study subjects,En-doscopic Retrograde New View(ERNV)was selected.The performance,image quality and intraoper-ative and postoperative complications were evaluated.To evaluate whether all the experimental ani-mals could complete the relevant endoscopy.Verify ERNV's operating performance,including whether the duodenoscope can enter the biliary tract smoothly,and made sure whether the injection,suction,and instrument channels were unobstructed.Choledochoscope image clarity,color resolu-tion,image deformation and distortion,accurate evaluation of lumen conditions and clear observation of mucosal surface conditions were analyzed.Whether there were operant injuries such as bleeding and perforation,as well as adverse events such as respiratory depression and cardiac arrest.The sur-vival status and adverse reactions of all pigs were observed.Results:The choledochoscope was successfully inserted into the bile duct of 6 miniature pigs.The product had good operation perfor-mance and could enter the bile duct through the duodenoscope smoothly.The injection,suction and instrument channels were relatively smooth.In addition,the endoscopic images are clear,with better color resolution,and without image deformation and distortion,which can realize accurate evaluation of the conditions in the lumen and observe the mucosal surface conditions more clearly.No bile duct stenosis or dilatation occurred in all miniature pigs,and the bile duct mucosa was smooth,without hyperemia and edema,and no abnormal thickening or bending of mucous vessels.During the exami-nation,there were no operational injuries such as bleeding and perforation,and no adverse events such as respiratory depression and cardiac arrest occurred.The vital signs of all miniature pigs tended to be stable after operation,and the survival state was good,and there were no complications such as cholangitis,bleeding and perforation.Conclusion:ERNV has good clinical safety and efficacy,ex-cellent operation performance and excellent image quality,and is worthy of clinical application.
