Role and mechanism of gut microbiota and its metabolites in host defense against infection
10.3760/cma.j.cn121430-20231011-00860
- VernacularTitle:肠道菌群及其代谢产物在宿主抵御感染中的作用及机制
- Author:
He JIN
1
;
Li GUAN
;
Shilan LUO
;
Yuanyuan ZHANG
;
Jinhui YUAN
;
Huaping LIANG
;
Junyu ZHU
Author Information
1. 陆军军医大学大坪医院战伤感染与特需药品研究室，创伤与化学中毒全国重点实验室，重庆 400042
- Keywords:
Gut microbiota;
Infection;
Resistance;
Tolerance
- From:
Chinese Critical Care Medicine
2024;36(3):326-331
- CountryChina
- Language:Chinese
-
Abstract:
The interaction of gut microbiota and its metabolites with the host not only plays an important role in maintaining gut homeostasis and host health, but also is a key link in responding to pathogen infections. A thorough understanding of the changes in gut microbiota and its metabolites during infection, as well as their role and mechanism in host defense against infection, is helpful to guide anti-infection treatment. This review focuses on the role of gut microbiota and their metabolites in host defense against bacterial, fungal, and viral infections, and reveals that they can exert anti-infection effects through resistance mechanisms (inducing antimicrobial substances, training immunity, inhibiting pathogen respiration, directly neutralizing pathogens, immune regulation) and tolerance mechanisms (altering energy metabolism patterns of microbiota, cell proliferation and tissue damage repair, maintaining physiological signal transduction in extraintestinal organs, inflammation regulation, maintaining the integrity of the intestinal barrier), and also summarizes measures to regulate gut microbiota against pathogen infections, in order to provide more ideas for novel anti-infection prevention and treatment strategies targeting gut microbiota and its metabolites.
