Interaction between NOD-like receptor protein 3 inflammatory corpuscles and mitochondrial dysfunction in the pathogenesis of septic cardiomyopathy

VernacularTitle:NLRP3炎症小体与线粒体功能障碍在脓毒性心肌病发病机制中的交互作用
Author: Yufan YUAN ¹ ; Qi SHEN ; Jinlan JIN
Author Information

1. 广州中医药大学深圳医院（福田）重症医学科，广东深圳　518034
Keywords: Septic cardiomyopathy; NOD-like receptor protein 3; Mitochondrial dysfunction; Interaction
From: Chinese Critical Care Medicine 2024;36(3):313-319
CountryChina
Language:Chinese
Abstract: Septic cardiomyopathy (SCM) has a high incidence and complex pathogenesis, which can significantly increase the mortality of sepsis patients. NOD-like receptor protein 3 (NLRP3) inflammatory corpuscles play an important role in the pathogenesis of SCM. Mitochondrial dysfunction in cardiomyocytes is also one of the important pathogenesis of SCM. Activation of NLRP3 inflammatory corpuscles is closely related to mitochondrial dysfunction. The study of interaction mechanism between the two is helpful to find a new therapeutic scheme for SCM. This article reviews the interaction between NLRP3 inflammatory corpuscles and mitochondrial dysfunction in the pathogenesis of SCM, as well as the related mechanisms of traditional Chinese medicine (TCM) prevention and treatment of SCM, providing theoretical reference for further exploring therapeutic targets for SCM.