Research progress on the role of N6-methyladenosine methylation in the pathogenesis and development of respiratory diseases
10.3760/cma.j.cn121430-20230223-00108
- VernacularTitle:N6-腺苷酸甲基化修饰在呼吸系统疾病发生发展中作用的研究进展
- Author:
Haibo LI
1
;
Jingfan YANG
;
Yanqin QIN
;
Jiansheng LI
Author Information
1. 河南中医药大学，河南省中医药防治呼吸病重点实验室，呼吸疾病中医药防治省部共建协同创新中心，郑州 450046
- Keywords:
N6-methyladenosine;
RNA methylation;
Respiratory disease;
Research progress
- From:
Chinese Critical Care Medicine
2024;36(3):303-307
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine (m6A) is one of the most common post-transcriptional modifications of eukaryotic mRNA. The m6A modification accelerates mRNA metabolism and translation, and plays an important role in cell differentiation, embryonic development and stress response. As a reversible epigenetic modification, m6A modification plays an important role in many physiological and pathological processes. The m6A modification is closely related to the occurrence and progression of respiratory diseases, and the m6A modification regulatory factor may be a potential target for regulating respiratory diseases. This article reviews the role of m6A modification in the development of respiratory diseases such as lung cancer, acute lung injury (ALI), asthma, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD). The purpose of m6A modification is to provide a reference for the pathogenesis of respiratory diseases and the study of targets.
