Research progress on the organ-protective effect of Maresin-1 in sepsis

VernacularTitle:Maresin-1对脓毒症器官保护作用的研究进展
Author: Lili TANG ¹ ; Moxiang GONG ; Qiao CHEN ; Zhiyong SU ; Xiaoyue LI
Author Information

1. 遵义医科大学第五附属（珠海）医院重症医学科，广东珠海　519100
Keywords: Maresin-1; Sepsis; Sepsis-associated organ injury; Excessive inflammatory reaction
From: Chinese Critical Care Medicine 2024;36(2):211-215
CountryChina
Language:Chinese
Abstract: Sepsis is a fatal organ dysfunction caused by the uncontrolled inflammatory response of the host to infection. Excessive inflammatory reaction is the core factor in the occurrence and development of sepsis, the degree of organ dysfunction is directly related to the prognosis of sepsis. Timely intervention of excessive inflammatory response and alleviation of organ function damage are essential to improve the prognosis of sepsis. Maresin-1 (MaR-1) is a newly discovered endogenous specific pro-inflammatory resolution mediator, which plays a role of anti-inflammatory, pro-inflammatory regression and organ protection in sepsis, and may be a new target for the treatment of sepsis. This article reviews the research progress of the role of MaR-1 in the regulation of inflammation and organ protection in sepsis, in order to provide reference for the clinical development of new drugs for the treatment of sepsis.