Research advance on the role of mitochondrial dysfunction and releasing mitochondrial DNA in sepsis-induced acute lung injury
10.3760/cma.j.cn121430-20230828-00702
- VernacularTitle:线粒体功能障碍及线粒体DNA释放在脓毒症相关性急性肺损伤中作用的研究进展
- Author:
Jiuzhi ZHANG
1
Author Information
1. 大连医科大学附属第一医院重症医学科，辽宁大连 116021
- Keywords:
Sepsis;
Sepsis-induced acute lung injury;
Mitochondrial function;
Mitochondrial DNA
- From:
Chinese Critical Care Medicine
2024;36(1):102-105
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis-induced acute lung injury (ALI) is a serious condition with a high incidence. Mitochondrial dysfunction and the release of mitochondrial DNA (mtDNA) play a crucial role in the occurrence and development of sepsis-induced ALI. In sepsis, mitochondrial dysfunction causes energy depletion of cells and dysfunction of tissue cell repair mechanisms, leading to ALI. In addition, the release of mtDNA leads to a more intense inflammatory response, exacerbating sepsis-induced ALI. This article reviews the pathophysiological mechanism of mitochondrial dysfunction and mtDNA release in sepsis and the current research status, in order to provide direction for the evaluation, treatment and prevention of sepsis-induced ALI.
