New research direction of organ dysfunction caused by hemorrhagic shock: mechanisms of mitochondrial quality control
10.3760/cma.j.cn121430-20230711-00510
- VernacularTitle:失血性休克导致器官功能障碍的新研究方向
- Author:
Zheng ZHANG
1
;
Hongjie DUAN
;
Jiake CHAI
;
Xiaofang ZOU
;
Shaofang HAN
;
Hailiang BAI
;
Yufang ZHANG
;
Huiting YUN
;
Ran SUN
Author Information
1. 河北北方学院研究生学院，河北张家口 075000
- Keywords:
Hemorrhagic shock;
Multiple organ dysfunction;
Mitochondrial quality control;
Mitochondrial dysfunction
- From:
Chinese Critical Care Medicine
2024;36(1):93-97
- CountryChina
- Language:Chinese
-
Abstract:
Hemorrhagic shock (HS) is one of the leading causes of death among young adults worldwide. Multiple organ dysfunction in HS is caused by an imbalance between tissue oxygen supply and demand, which is closely related to the poor prognosis of patient. Mitochondrial dysfunction is one of the key mechanisms contributing to multiple organ dysfunction in HS, while mitochondrial quality control regulates mitochondrial function through a series of processes, including mitochondrial biogenesis, mitochondrial dynamics, mitophagy, mitochondrial-derived vesicles, and mitochondrial protein homeostasis. Modulating mitochondrial quality control can improve organ dysfunction. This review aims to summarize the effects of mitochondrial dysfunction on organ function in HS and discuss the potential mechanisms of mitochondrial quality control, providing insights into the injury mechanisms underlying HS and guiding clinical management.
