Health Economic Evaluation of Neonatal Phenylketonuria(PKU)Screening in Dongguan/
- VernacularTitle:东莞市新生儿苯丙酮尿症筛查的卫生经济学评价研究
- Author:
Guozhu CHEN
1
;
Liai ZOU
;
Xiaoling HUANG
;
Shiying ZHONG
;
Wei YUAN
Author Information
1. 东莞市妇幼保健院 广东 东莞 523110
- Keywords:
neonatal;
phenylketonuria;
health economics evaluation;
Dongguan
- From:
Chinese Health Economics
2024;43(3):78-81
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To acquire the implementation effect of the neonatal Phenylketonuria(PKU)Screening Project in Dong-guan,and evaluate its economic effectiveness,so as to provide references for the prevention and control policies of genetic defects in newborns.Methods:Choosing PKU children born in Dongguan from January 2012 to December 2021(excluding BH4 deficien-cy)as the subjects,conduct the cost-benefit and cost-effectiveness analysis on the prevention and treatment of PKU.The relevant data was gained from questionnaire surveys,statistical data,medical service prices of non-profit medical institutions in Dongguan,and relevant literature materials.Results:In the past 10 years,1 245 243 newboms were screened for PKU in Dongguan,the average screening rate is 93.32％.Among them,29 were diagnosed with PKU,with a positive rate of 1:42939.During continuous follow-up,23 cases were diagnosed.Among the 23 follow-up cases,only 1 had intelligence at the critical value,while the rest were normal.The total cost of screening is 29.728 7 million,and the total benefit is 14.239 9 million.The cost-effectiveness ratio is 102.51:1,the cost-benefit ratio is 1:4.79.Conclusion:Neonatal phenylketonuria(PKU)screening in Dongguan has significant social and economic benefits.It's necessary to continue and improve the screening work,especially the policy which can benefit the PKU's full life.
