Research progress in the mechanism of stimulator of interferon genes in type 2 diabetes mellitus and its microvascular complication

VernacularTitle:干扰素基因刺激因子在2型糖尿病及其微血管并发症中作用机制的研究进展
Author: Min LI ¹ ; Xiaoyan QI ; Zhenyu YANG ; Weiran YE ; Yanbo LI
Author Information

1. 518000 深圳大学附属华南医院内分泌科
Keywords: Diabetes mellitus,type 2; Stimulator of interferon genes; Islet β cell; Microvascular complications
From: Chinese Journal of Diabetes 2024;32(3):227-230
CountryChina
Language:Chinese
Abstract: Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease that can lead to the damage of multiple tissues and organs throughout the body.Stimulator of interferon genes(STING)is an endoplasmic reticulum membrane protein that acts as an indirect cytoplasmic DNA sensor.The activation of the STING signaling pathway may be involved in T2DM and its microvascular complications through various mechanisms.This article reviews the research progress in the mechanism of STING in T2DM and its microvascular complications.