Research progress of glycolysis induced islet β cell dedifferentiation based on HIF-1α/PFKFB3 signaling pathway
10.3969/j.issn.1006-6187.2024.03.013
- VernacularTitle:缺氧诱导因子1α/6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3信号通路对糖酵解诱导胰岛β细胞去分化作用的研究进展
- Author:
Xi ZHANG
1
;
Haoyue WEI
;
Daihao WEI
;
Kun MA
;
Yingkai SHEN
;
Yanqin HUANG
Author Information
1. 250014 济南,山东中医药大学中医学院
- Keywords:
Diabetes mellitus,type 2;
Dedifferentiation;
Glycolysis;
HIF-1α/PFKFB3 signaling pathway;
Islet β cells
- From:
Chinese Journal of Diabetes
2024;32(3):222-226
- CountryChina
- Language:Chinese
-
Abstract:
Islet β cell dedifferentiation is one of the important reasons leading to insulin secretion defect or insulin resistance in patients with type 2 diabetes mellitus(T2DM).HIF-1α/PFKFB3 signaling pathway is a newly discovered biological pathway related to T2DM,which is involved in the induction of islet β cells dedifferentiation by anaerobic glycolysis under high glucose environment.This article reviews the research progress of the role of HIF-1α/PFKFB3 signaling pathway in glycolysis induced islet β cell dedifferentiation.
