Study on the mechanism of improving islet β-cell function in patients with type 2 diabetes mellitus by Alogliptin benzoate
10.3969/j.issn.1006-6187.2024.03.003
- VernacularTitle:苯甲酸阿格列汀改善2型糖尿病患者胰岛β细胞功能机制的研究
- Author:
Xi YANG
1
;
Pu ZHANG
;
Jingxuan MA
;
Mengchu SUN
;
Liqin LI
;
Jun WANG
Author Information
1. 071000 保定市第一中心医院内分泌科
- Keywords:
Alogliptin benzoate;
Diabetes mellitus,type 2;
Autophagy;
Islet β-cell
- From:
Chinese Journal of Diabetes
2024;32(3):173-176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Alogliptin benzoate on the serum autophagy markers in type 2 diabetes mellitus(T2DM)patients.Methods Eighty newly diagnosed T2DM patients who visited the Department of Endocrinology in Baoding No.1 Central Hospital from December 2021 to October 2022 were randomly divided into a group treated with Metformin(Met group,n=40)and a group treated with Met and Alog(Met+Alog group,n=40).The differences in BMI,WHR,FPG,HbA1c,Atg7 and Beclin-1 between two groups before and after 12 weeks of treatment were compared.Results After treatment,the levels of Atg7 and Beclin-1 increased in both groups(P<0.05),while FPG,HbA1c and HOMA-IR decreased(P<0.05).After treatment,Atg7,Beclin-1 and HDL-C in Met+Alog group were higher than those in Met group(P<0.05).Pearson correlation analysis showed that Atg7 was negatively correlated with BMI,FPG and HbA1c(P<0.05);Beclin-1 was positively correlated with HDL-C(P<0.05),and negatively correlated with BMI,FPG,HbA1c,and TG(P<0.05).Meta linear regression analysis showed that BMI was the influencing factor of Atg7,while BMI and HDL-C were the influencing factors of Beclin-1.Conclusion Alogliptin benzoate may improve islet β cell function by up-regulating the expression of autophagy related factors Atg7 and Beclin-1 in patients with T2DM.
