Drug rash with eosinophilia and systemic symptoms syndrome following cholestatic hepatitis A: a case report.
10.3350/kjhep.2012.18.1.84
- Author:
Jihyun AN
1
;
Joo Ho LEE
;
Hyojeong LEE
;
Eunsil YU
;
Dan Bi LEE
;
Ju Hyun SHIM
;
Sunyoung YOON
;
Yumi LEE
;
Soeun PARK
;
Han Chu LEE
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. hch@amc.seoul.kr
- Publication Type:Case Reports
- Keywords:
Hepatitis A;
Drug hypersensitivity;
DRESS syndrome;
Acute kidney injury
- MeSH:
Acute Kidney Injury/diagnosis;
Anti-Bacterial Agents/*adverse effects/therapeutic use;
Cefotaxime/adverse effects/therapeutic use;
Cholestasis/complications/*diagnosis;
Cytomegalovirus/genetics;
Cytomegalovirus Infections/drug therapy/virology;
DNA, Viral/analysis;
Eosinophilia/etiology;
Exanthema/*chemically induced/pathology;
Ganciclovir/therapeutic use;
Hepatitis A/complications/*diagnosis/drug therapy;
Humans;
Hydrocortisone/therapeutic use;
Immunoglobulins/therapeutic use;
Male;
Syndrome;
Young Adult
- From:The Korean Journal of Hepatology
2012;18(1):84-88
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hepatitis A virus (HAV) infections occur predominantly in children, and are usually self-limiting. However, 75-95% of the infections in adults are symptomatic (mostly with jaundice), with the illness symptoms usually persisting for a few weeks. Atypical manifestations include relapsing hepatitis, prolonged cholestasis, and complications involving renal injury. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, drug-induced hypersensitivity reaction characterized by skin rash, fever, lymph-node enlargement, and internal organ involvement. We describe a 22-year-old male who presented with acute kidney injury and was diagnosed with prolonged cholestatic hepatitis A. The patient also developed DRESS syndrome due to antibiotic and/or antiviral treatment. To our knowledge, this is the first report of histopathologically confirmed DRESS syndrome due to antibiotic and/or antiviral treatment following HAV infection with cholestatic features and renal injury.
