Correlation between serum uric acid/high density lipoprotein cholesterol ratio and type 2 diabetic peripheral neuropathy
10.3969/j.issn.1006-6187.2024.02.003
- VernacularTitle:血尿酸/高密度脂蛋白胆固醇比值与2型糖尿病周围神经病变相关性的研究
- Author:
Rurong WANG
1
;
Yangyang WANG
;
Huazhen TANG
;
Jingxian DING
Author Information
1. 213161 常州市武进中医医院内分泌科
- Keywords:
Serum uric acid/high density lipoprotein cholesterol ratio;
Diabetes mellitus,type 2;
Diabetic peripheral neuropathy;
Nerve conduction velocity
- From:
Chinese Journal of Diabetes
2024;32(2):97-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between blood uric acid/HDL-C ratio(UHR)and peripheral neuropathy(DPN)in T2DM.Methods A total of 127 T2DM patients admitted to the Endocrinology Department of Wujin Traditional Chinese Medicine Hospital in Changzhou City from August 2022 to August 2023 were selected.They were divided into a simple T2DM group(n=62)and a combined DPN group(DPN,n=65)based on whether or not they had DPN.Compare two groups of general information,biochemical indicators,and UHR.Results Compared with the T2DM group,DPN group DM course of disease,HbA1c,FPG,FIns,HOMA-IR,TG,vibration sensation threshold(VPT),hypersensitive C-reactive protein(hs-CRP),blood uric acid(SUA),and UHR(P＜0.05),HDL-C,tibial nerve motor nerve conduction velocity(mNCV),and superficial peroneal nerve sensory nerve conduction velocity (sNCV)decreased(P＜0. 05). Spearman correlation analysis showed that UHR was positively DM duration of disease,HbA1c,FPG,HOMA?IR,TG,VPT,hs?CRP,and SUA(P＜0. 05),negatively correlated with mNCV,sNCV,and HDL?C(P＜0. 05). Logistic regression analysis showed that UHR,DM duration, hs?CRP,and HbA1c were the influencing factors of DPN. Conclusion Elevated UHR is a influencing factor for the occurrence of DPN in T2DM patients and has good predictive value for DPN.
