Research progress on the relationship between macrophage polarization and type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.01.014
- VernacularTitle:巨噬细胞极化与2型糖尿病关系的研究进展
- Author:
Jialiang GAO
1
;
Ting YANG
;
Hongwu WANG
Author Information
1. 301617 天津中医药大学研究生院
- Keywords:
Macrophage polarization;
Diabetes mellitus,type 2;
Inflammation
- From:
Chinese Journal of Diabetes
2024;32(1):65-69
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the incidence of type 2 diabetes mellitus(T2DM)keeps increasing in China,and seriously affects people's health.The M1/M2 polarization of macrophages is unbalanced in patients with T2DM,which is manifested by the increase of pro-inflammatory M1 macrophages and the decrease of anti-inflammatory M2 macrophages.Macrophage polarization imbalance can cause insulin resistance or damage pancreatic islets β cells through various ways.Adjusting the polarization of macrophages plays a therapeutic role in T2DM.This article reviews the research progress on the relationship between macrophage polarization and T2DM.
