Long-term effects and mechanisms of paternal environment on glucose and lipid metabolism in offspring
10.3969/j.issn.1006-6187.2024.01.013
- VernacularTitle:父代营养环境对子代糖脂代谢影响的研究进展
- Author:
Jia ZHENG
1
;
Ling ZHANG
;
Junqing ZHANG
Author Information
1. 100034 北京大学第一医院内分泌科
- Keywords:
Paternal environment;
Glucose and lipid metabolism;
Offspring;
Epigenetics
- From:
Chinese Journal of Diabetes
2024;32(1):62-64
- CountryChina
- Language:Chinese
-
Abstract:
The developmental origins of health and disease(DOHaD)suggests that a poor maternal developmental environment during pregnancy can significantly increase the risk of chronic metabolic diseases such as obesity,diabetes mellitus(DM),and cardiovascular disease in offspring during adulthood.The adverse environmental factors of the father's generation influence the glucose and lipid metabolism of the offspring.The environmental factors exposed by the father before fertilization,such as over nutrition,obesity,diabetes caused cross generation reprogramming in offspring,and develop glucose and lipid metabolism disorders,which can last for one or more generations.Currently,paternal origin of health and disease(POHaD)has received widespread attention and has important scientific value and social significance.This article reviews the research progress on the impact of parental nutritional environment on offspring glucose metabolism.
