The therapeutic effect of continuous blood purification on diabetic lactic acidosis
10.3969/j.issn.1006-6187.2024.01.008
- VernacularTitle:连续性血液净化对糖尿病乳酸酸中毒的治疗作用
- Author:
Chunqin DAI
1
;
Peng QIAN
;
Daoli JIANG
Author Information
1. 215000 苏州大学附属第二医院血液净化中心
- Keywords:
Diabetic lactic acidosis;
Continuous blood purification;
Therapeutic effect
- From:
Chinese Journal of Diabetes
2024;32(1):37-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of continuous blood purification on diabetic lactic acidosis(DLA).Methods 60 DLA patients who were treated at our hospital Blood Purification Center from January 2020 to January 2023 were randomly divided into conventional treatment group(Con)and continuous blood purification group(CBP),with 30 cases in each group.The changes of anion gap(AG),pH,lactic acid(Lac),FPG,2 hPG,HbA1c,alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),serum creatinine(Scr),urea nitrogen(BUN),cystatin C(CysC),blood potassium(K+),C-reactive protein(C-RP),acute and chronic health evaluation scoring system Ⅱ(APACHEⅡ)and mortality within 28 days were compared between the two groups.Results After 48 h of treatment,the clearance rate of Lac in CBP group was higher than that in Con group(P<0.05).The pH value of CBP group was higher than Con group.The levels of AG,Lac,FPG,2 hPG,HbA1c,ALT,AST,TBIL,Scr,BUN,CysC,K+,C-RP and APACHEⅡ score were lower in CBP group than those in Con group(P<0.05).The 28-day mortality rate of the CBP group was lower than that of the Con group(P<0.05).Conclusion Continuous blood purification combined with routine treatment in DLA patients can increase Lac clearance and improve the prognosis.
