Relationship between polymorphism of resistin gene and metabolic associated fatty liver disease in type 2 diabetes mellitus patients in middle and high altitude areas
10.3969/j.issn.1006-6187.2024.01.006
- VernacularTitle:中高海拔地区2型糖尿病患者抵抗素基因多态性与代谢相关脂肪性肝病相关性的研究
- Author:
Beibei WANG
1
;
Wei LUO
;
Peiyun FAN
;
Lingling ZHAO
;
Yanping JIANG
;
Zhuoma DAWA
;
Lin ZHOU
;
Yongli YAO
Author Information
1. 810000 西宁,青海省人民医院内分泌二科
- Keywords:
Diabetes mellitus,type 2;
Metabolic associated fatty liver disease;
Resistin;
Genepoly-morphism;
Middle and high altitude
- From:
Chinese Journal of Diabetes
2024;32(1):23-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between polymorphism of resistin(RETN)gene and metabolic associated fatty liver disease(MAFLD)in type 2 diabetes mellitus(T2DM)patients in middle and high altitude areas.Methods A total of 400 patients with T2DM in Qinghai area were recruited and divided into simple T2DM group(T2DM,n=200)and T2DM combined with MAFLD group(T2DM+ MAFLD,n=200)according to liver ultrasonography.Healthy individuals confirmed by physical examination were selected as the normal control group(NC,n=180).Plasma resistin levels were measured by ELISA.The polymorphism of RETN-420C/G and +299G/A genes were detected by PCR sequencing.Results By comparing the polymorphism of RETN-420C/G gene in each group,it was found that the frequencies of G/G genotype and G allele frequency in T2DM+MAFLD group were higher than those in NC group and T2DM group(P<0.05),while the frequencies of C/C genotype and C allele frequency were lower than those in NC group and T2DM group(P<0.05).The risk of MAFLD increased by 1.571,2.126 and 1.537 times respectively in T2DM patients with C/G,G/G genotype and G allele.Logistic regression analysis showed that G/G genotype was a risk factor for MAFLD in T2DM patients.By comparing the polymorphism of RETN+299G/A gene in each group,it was found that A allele frequency in T2DM+MAFLD group was higher than that in NC group and T2DM group,while G allele frequency was lower than that in NC group and T2DM group(P<0.05).The allele A increased the risk of MAFLD in T2DM patients by 1.432 times compared to allele G.Conclusion RETN gene-420C/G locus G/G genotype increases the risk of T2DM combined with MAFLD in middle and high altitudeareas.
