Study on the correlation between serum neuregulin 4 and metabolic associated fatty liver disease in type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2023.12.008
- VernacularTitle:2型糖尿病患者血清神经调节蛋白4与代谢相关脂肪性肝病相关性的研究
- Author:
Yumei ZHONG
1
;
Xueyu ZHONG
;
Weiping ZHOU
;
Wan TANG
;
Wei XIANG
;
Jin XU
Author Information
1. 443000 宜昌市第二人民医院内分泌科
- Keywords:
Diabetes mellitus,type 2;
Neuregulin 4;
Metabolic associated fatty liver disease
- From:
Chinese Journal of Diabetes
2023;31(12):921-924
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum neuregulin 4(Nrg4)level and metabolic associated fatty liver disease(MAFLD)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 240 T2DM patients admitted to the Department of Endocrinology of Second People's Hospital of Yichang from June 2021 to August 2022 were collected and divided into simple T2DM group(n=120)and MAFLD group(MAFLD,n=120).120 healthy individuals were selected as the normal control(NC)group.Results The serum Nrg4 decreased gradually from NC group,T2DM group to MAFLD group(P＜0.05).Pearson correlation analysis showed that serum Nrg4 was negatively correlated with WC,HOMA-IR and hs-CRP(P＜0.05),and positively correlated with HDL-C(P＜0.05).Logistic regression analysis showed that Nrg4,WC,HOMA-IR and hs-CRP were the influencing factors of MAFLD.After adjusting for age,sex,smoking history,BMI,TC,TG,HDL-C,LDL-C,FPG,FIns,HbA1c and other factors,serum Nrg4 was still the influencing factor of MAFLD.Conclusion The decrease of serum Nrg4 is a risk factor for T2DM combined with MAFLD.
