Correlation between serum KIM-1,NGAL and diabetic kidney disease remission after gastric bypass surgery in obese patients
10.3969/j.issn.1006-6187.2023.12.007
- VernacularTitle:血清肾损伤分子1、中性粒细胞明胶酶相关脂质运载蛋白与肥胖糖尿病肾脏疾病患者胃旁路术后肾脏功能改善相关性的研究
- Author:
Hongen YU
1
;
Juan SUN
;
Xiaoshuang LI
Author Information
1. 221004 徐州医科大学第一临床医学院
- Keywords:
Obesity;
Gastric bypass surgery;
Diabetic kidney disease;
Kidney injury molecule-1;
Neutrophil gelatinase-associated lipocalin
- From:
Chinese Journal of Diabetes
2023;31(12):916-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum renal injury molecule-1(KIM-1)and neutrophil gelatinase-associated lipocalin(NGAL)in the remission of diabetic kidney disease(DKD)after gastric bypass surgery in obese DKD patients.Methods Seventy-nine obese patients with DKD who received gastric bypass surgery in our hospital from January 2021 to January 2022 were selected and divided into DKD remission group(n= 47)and DKD non-remission group(n=32)according to whether UACR decreased to normal level after surgery.Preoperative and postoperative general data were collected and biochemical indices,serum KIM-1 and NGAL levels were detected.Results None of the 79 obese DKD patients had intraoperative complications or switched to laparotomy.BMI,FPG,HbA1c,SBP,DBP,TC,TG,LDL-C,SUA,UACR,KIM-1 and NGAL were decreased after surgery,while HDL-C was increased after surgery(P＜0.05).SBP,DBP,Scr,BUN,UACR,KIM-1 and NGAL in remission group were lower than those in non-remission group(P＜0.05).Spearman correlation analysis showed that the levels of KIM-1 and NGAL were positively correlated with Scr,BUN and UACR(P＜0.05),but negatively correlated with eGFR(P＜0.05).Logistic regression analysis showed that SBP,UACR,KIM-1 and NGAL were influencing factors for DKD remission after gastric bypass surgery.The areas under ROC curve of serum KIM-1,NGAL and combined prediction of DKD remission were 0.801,0.757 and 0.863,respectively.Conclusion Serum KIM-1 and NGAL can predict DKD remission in obese DKD patients after gastric bypass surgery.
