Serum SHBG level in male adults with different glucose tolerance and its correlation with lipid metabolism and visceral fat area
10.3969/j.issn.1006-6187.2023.12.003
- VernacularTitle:不同糖耐量成年男性性激素结合球蛋白与脂代谢、腹腔内脏脂肪面积相关性的研究
- Author:
Jiaqi YAO
1
;
Xiujing WANG
;
Tianxiao HU
;
Huiling SHEN
;
Yao XU
;
Qingying TAN
Author Information
1. 310013 杭州,中国人民解放军联勤保障部队第九〇三医院内分泌科
- Keywords:
Different glucose tolerance;
Male;
Sex hormone-binding globulin;
Lipid metabolism;
Visceral fat area
- From:Chinese Journal of Diabetes
2023;31(12):894-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between sex hormone-binding globulin(SHBG)and lipid metabolism and visceral fat area(VFA)in male adults with different glucose tolerance.Methods A total of 473 male subjects were enrolled from the outpatient clinic and ward in PLA NO.903 Hospital from January 2018 to December 2020.All the subjects were divided into three groups according to OGTT results:normal glucose tolerance group(NGT,n=179),impaired glucose regulation group(IGR,n=90)and newly diagnosed type 2 diabetes mellitus group(T2DM,n=204).Serum SHBG level,abdominal visceral fat area(VFA)and biochemical indexes were compared among the three groups.Results Compared with NGT group,WC,WHR,BMI,HbA1c,FPG,2 hPG,2 hIns,TG and VFA were increased(P＜0.05),while SHBG was decreased(P＜0.05)in IGR group.WC,SBP,DBP,HbA1c,FPG,2 hPG,2 hIns,HOMA-IR,TG,FFA,VFA and VFA/SFA were increased,while HOMA-β,SHBG were decreased(P＜0.05)in T2DM group.Compared with IGR group,SBP,HbA1c,FPG,2 hPG,2 hIns and HOMA-IR were increased,HOMA-β was decreased in T2DM group(P＜0.05).Pearson correlation analysis showed that SHBG was positively correlated with HDL-C(P＜0.01),but was negatively correlated with WC,WHR,BMI,2 hIns,SUA,TG,VFA and SFA(P＜0.05 or P＜0.01).Multivariable linear regression analysis showed that HDL-C,TG and VFA were the influencing factors for SHBG.Conclusion Serum SHBG is closely related to abdominal obesity and lipid metabolism.Increasing the level of SHBG can reduce visceral fat accumulation and improve IR.
