Advances in the mechanism-of-action of circRNA in Parkinson's disease
10.3969/j.issn.1671-7856.2024.02.020
- VernacularTitle:环状RNA在帕金森病中作用机制研究进展
- Author:
Juan LIU
1
;
Yanjie LI
;
Hewei QIN
;
Luyao MA
;
Nannan ZHAO
;
Zhenhua XU
Author Information
1. 河南中医药大学康复医学院,郑州 450046
- Keywords:
Parkinson's disease;
circRNA;
oxidative stress;
neuroinflammation;
biomarkers
- From:
Chinese Journal of Comparative Medicine
2024;34(2):161-166
- CountryChina
- Language:Chinese
-
Abstract:
PD is a neurodegenerative disease characterized by degenerative death of dopaminergic neurons in the substantia nigra,exhibiting a range of motor and non-motor symptoms with serious effects on quality of life.circRNA is a covalently closed-loop non-coding RNA that plays a major role in PD progression.This article reviews the involvement of circRNA in oxidative stress,regulation of transcription,neuroinflammation,autophagy,and α-synuclein.
