Advances in research on mechanisms related to myocardial regeneration in neonatal murine
10.3969/j.issn.1671-7856.2024.02.018
- VernacularTitle:新生鼠心肌再生相关调节机制的研究进展
- Author:
Mengqi CHEN
1
,
2
;
Tingting LIU
;
Fangling SUN
;
Xin TIAN
;
Wenrong ZHENG
;
Zixin ZHU
;
Yufeng WANG
;
Liansu MA
;
Wen WANG
Author Information
1. 首都医科大学宣武医院实验动物室,北京 100053
2. 北京市老年病医疗研究中心,北京 100053
- Keywords:
myocardial regeneration;
cardiovascular disease;
cell proliferation;
neonatal heart;
molecular mechanism
- From:
Chinese Journal of Comparative Medicine
2024;34(2):144-153
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease is a health hazard to humans and systolic heart failure due to myocardial infarction is a major cause of death.It was previously thought that myocardial cells of the adult mammalian heart possess a limited ability to proliferate and self-renew.However,it has been widely reported that mammals have the ability to regenerate the myocardium,which is restricted to early postnatal life,and that it is strong enough to repair damaged heart tissue.The discovery of myocardial regeneration in neonatal hearts has provided an ideal animal model to investigate the mechanisms that affect myocardial regeneration,and many mechanisms that reverse myocardial cell cycle arrest and promote myocardial regeneration have been revealed.In this article,we review the factors affecting gene expression for myocardial regeneration(e.g.,ncRNAs and transcription factors),myocardial regeneration-related signaling pathways,and the regulation of myocardial regeneration by non-myocardial cells(e.g.,extracellular matrix,immune response,and epicardium)to provide directions for achieving myocardial regeneration after myocardial injury in adult mammals.
