Research progress of berberine in the field of neuroprotection in ischemic stroke

VernacularTitle:小檗碱在缺血性脑卒中神经保护领域的研究进展
Author: Hongyu LI ^{1
,

2} ; Rui LAN ; Manman WANG ; Weiwei WANG ; Yong ZHANG ; Chen TANG ; Shuang LIU
Author Information

1. 河南中医药大学第一附属医院脑病中心,郑州 450000
2. 河南中医药大学第一临床医学院,郑州 450000
Keywords: ischemic stroke; berberine; risk factors; neuroprotection; mechanisms of brain injury
From: Chinese Journal of Comparative Medicine 2024;34(2):129-136
CountryChina
Language:Chinese
Abstract: Berberine is a natural isoquinoline alkaloid that was initially used as a broad-spectrum antibacterial agent in clinical treatment of enteritis,peptic ulcers,chronic gastritis,pneumonia,and other diseases.In recent years,in-depth study of the pharmacological effects of berberine has provided increasing evidence that berberine has neuroprotective effects on ischemic stroke.In this review,we introduce the effect of berberine on risk factors of ischemic stroke and discuss the neuroprotective effects of berberine on various mechanisms of ischemic stroke in detail to provide a reference for clinical and basic research in this field.