Overview of in vitro skin models of transdermal drug delivery systems

VernacularTitle:经皮给药系统皮肤模型的研究进展
Author: Yan LIU ^{1
,

2
,

3} ; Xiaolei HU ; Kehong XU ; Hairong ZHAO ; Xiumei WU ; Zizhong YANG ; Chenggui ZHANG ; Yu ZHAO ; Pengfei GAO
Author Information

1. 大理大学药学院,云南大理 671000
2. 大理大学云南省昆虫生物医药研发重点实验室,云南大理 671000
3. 大理大学药用特种昆虫开发国家地方联合工程研究中心,云南大理 671000
Keywords: transdermal drug delivery system; skin model; application characteristics
From: Chinese Journal of Comparative Medicine 2024;34(2):122-128
CountryChina
Language:Chinese
Abstract: Skin modeling of transdermal drug delivery system refers to experimental models that mimic the structure and function of human skin to explore and evaluate absorption,penetration,and efficacy of medicines in transdermal drug delivery.It provides an alternative to traditional human skin experiments and reduces the use of human skin in medical research,which is convenient,controllable,and cost effective.For skin models of transdermal drug delivery systems,this article introduces commonly used animal skin models,artificial skin models,and recombinant human skin models from the perspective of the transdermal absorption pathway of medicines,and analyzes their advantages,disadvantages,and applications so provide references the research and development of transdermal formulations and topical therapies.