Research progress of non-coding RNA in methamphetamine-induced addiction and neurotoxicity

VernacularTitle:非编码RNA在甲基苯丙胺诱导成瘾及神经毒性作用的研究进展
Author: Shuwei ZHANG ¹ ; Hao CHENG ; Haowei WANG ; Lin MIAO ; Yi LI ; Lina GUAN ; Xiaofeng ZENG
Author Information

1. 国家卫健委毒品依赖和戒治重点实验室,昆明医科大学法医学院,昆明 650500
Keywords: methamphetamine; non-coding RNA; addiction; neurotoxicity
From: Chinese Journal of Comparative Medicine 2024;34(2):114-121
CountryChina
Language:Chinese
Abstract: Methamphetamine(METH)is highly addictive and neurotoxic,which causes cognitive and memory dysfunction in abusers.The harm of METH lies not only in its own toxicity,but also in the high physical and mental dependence of drug addicts,often causing mental disorders and violent behavior,bringing great safety risks to society.Non-coding RNA(ncRNA)does not encode proteins and is an important factor in regulating gene expression at the post-transcriptional level.Studies have shown that ncRNA plays an important regulatory role in methamphetamine-induced addiction and neurotoxicity,but the specific mechanism is unclear.This article reviews the current research progress of ncRNA in regulating METH-induced addiction and neurotoxicity to provide a reference for ncRNA as a forensic identification index and potential therapeutic target for METH abusers.