Research progress on the role of SHP-2 in tumor-associated macrophages
10.3969/j.issn.1671-7856.2024.01.023
- VernacularTitle:SHP-2在肿瘤相关巨噬细胞中的研究进展
- Author:
Xueliang WU
1
,
2
;
Jianchun FAN
;
Fei GUO
;
Qi ZHANG
;
Jun XUE
;
Ximo WANG
;
Guangyuan SUN
;
Jianling LIU
;
Lei HAN
;
Shuquan GAO
Author Information
1. 河北北方学院附属第一医院普通外科,河北张家口 075000
2. 河北北方学院附属第一医院肿瘤研究所,河北张家口 075000
- Keywords:
protein tyrosine phosphatase 2;
tumor-associated macrophages;
clinical research;
mechanism of action
- From:
Chinese Journal of Comparative Medicine
2024;34(1):171-176
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophages(TAMs)are the predominant cell group in the tumor microenvironment(TME)and are the most important regulatory cells of immune system suppression and tumor cell proliferation in TIME.Src homology-2 domain-containing protein tyrosine phosphatase 2(SHP-2)is a non-receptor protein tyrosine phosphatase that plays an important role in the transmission of signals from the cell surface to the nucleus.SHP-2 is a key intracellular regulatory factor mediating cell proliferation and differentiation and is involved in a variety of growth factor and cytokine signaling pathways linking the cell surface to the nucleus.Recent studies have shown that SHP-2 is a key enzyme in determining the function of TAMs,but because of its variable function,it plays different or even opposite roles in different solid TMEs.This paper reviews the function of SHP-2 in TAMs and related solid tumors to provide a comprehensive reference for tumor immunity and targeted therapy research.
