Progress in irisin and its upstream and downstream antidepressants
10.3969/j.issn.1671-7856.2024.01.017
- VernacularTitle:鸢尾素及其上下游抗抑郁的研究进展
- Author:
Jiala SANG
1
;
Shanshan LI
;
Xin CUI
;
Qingqing REN
;
Ruiling HOU
;
Xingfang PAN
;
Shenjun WANG
;
Meidan ZHAO
Author Information
1. 天津中医药大学实验针灸学研究中心,天津 301617
- Keywords:
depression;
irisin;
BDNF
- From:
Chinese Journal of Comparative Medicine
2024;34(1):130-138
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a major cause of disability and has adverse effects.Despite the many types of anti-depressants,clinical treatments of depression remain poor.Therefore,novel anti-depressant mechanisms need to be explored.The beneficial effects of irisin on the nervous system are gradually being elucidated,and studies have found that irisin has an anti-depressant effect,which may become a new treatment for depression.This study explored the mechanism of irisin and its upstream and downstream anti-depressants by reviewing the existing studies explaining the link between irisin and depression,and proposes that SIRT1/PGC-1α may mediate FNDC5/irisin to regulate BDNF to promote neurogenesis and improve depression,which provides a new idea to study irisin and its upstream and downstream anti-depressants.
