Research progress of traditional Chinese medicine for stroke on the basis of epigenetic regulation
10.3969/j.issn.1671-7856.2023.12.016
- VernacularTitle:基于表观遗传学调控的中医药治疗中风研究进展
- Author:
Xueqin FU
1
;
Rui LAN
;
Yong ZHANG
;
Manman WANG
;
Xuhuan ZOU
;
Weiwei WANG
Author Information
1. 河南中医药大学,郑州 450000
- Keywords:
epigenetics;
stroke;
traditional Chinese medicine;
DNA methylation;
non-coding RNA;
histone modification
- From:
Chinese Journal of Comparative Medicine
2023;33(12):104-111
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetics,a branch of molecular biology,plays a pivotal role in the pathological progression of ischemic stroke.Epigenetic modifications are intricately involved in the complex and dynamic processes that regulate gene expression,cellular injury response,motor function,and cognitive ability following stroke.This provides an effective framework for elucidating the targets and mechanisms of action underlying traditional Chinese medicine's treatment of ischemic stroke.Currently,the etiology and pathogenesis of ischemic stroke remain incompletely understood,with modern medical treatments still lacking sufficient efficacy.Traditional Chinese medicine possesses a unique advantage in treating ischemic stroke through its multi-level and multi-target comprehensive regulation.Recent studies have discovered that traditional Chinese medicine can participate in regulating abnormal epigenetic modifications during stroke treatment.This article primarily focuses on the theoretical foundation of traditional Chinese medicine for strokes by exploring its application in DNA methylation,non-coding RNA,histone modification research as well as explaining the epigenetic effects it exerts when treating strokes.The aim is to provide insights for future research and development of traditional Chinese medicine for cerebral ischemia.
