Subacute effect of CeO2NPs on organ structures and redox indicators in male mice
10.3969/j.issn.1671-7856.2023.12.010
- VernacularTitle:纳米二氧化铈亚急性染毒对雄性小鼠脏器结构和氧化还原指标的影响
- Author:
Qian ZHANG
1
;
Mingsheng HUANG
;
Li JIANG
;
Dongmei GU
;
Jun YIN
Author Information
1. 扬州大学比较医学中心,江苏 扬州 225000
- Keywords:
CeO2 NPs;
intraperitoneal administration;
histopathology;
redox indicator
- From:
Chinese Journal of Comparative Medicine
2023;33(12):62-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of CeO2 NP subacute exposure on body weight,organ structures,and redox indicators in male mice.Methods Thirty-five male ICR mice were randomly divided into five groups with seven mice in each group.Normal control and CeO2 NP(100,500,1000 and 5000 μg/kg)groups were included.Mice were injected with CeO2 NPs intraperitoneally every other day for 28 days.Results Compared with the control group,no significant difference was found in weight gain(P>0.05),but significant differences were observed in the liver coefficient,epididymal coefficient,and sperm survival rate(P<0.01).In the 5000 μg/kg group,CeO2 NPs were deposited in the liver and spleen,and granuloma was found SOD and GSH-Px activities in serum of the 100 μg/kg group were increased,while MDA content was decreased,which indicated the antioxidant effect of CeO2 NPs.With the increase in dose,oxidative stress induced by CeO2 NPs was enhanced.Conclusions Low-dose-CeO2 NPs are safe and exert an antioxidant effect.With the increase in dose,the toxicity of CeO2 NPs also increases gradually.
