Advances in the application of 5×FAD transgenic mice in Alzheimer's disease research
10.3969/j.issn.1005-4847.2024.02.014
- VernacularTitle:5×FAD转基因小鼠在阿尔茨海默病研究中的应用进展
- Author:
Yiduan LIU
1
;
Yixiao LIU
;
Xinyuan HAN
;
Yitong XIAO
;
Tianyuan YE
Author Information
1. 山东中医药大学康复医学院,济南 250355
- Keywords:
Alzheimer's disease;
5 × FAD transgenic mice;
learning and memory;
cognitive function
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(2):260-274
- CountryChina
- Language:Chinese
-
Abstract:
Transgenic 5 × FAD mice are APP/PS1 transgenic mice carrying five familial Alzheimer's disease(AD)gene mutations.Beta-amyloid precursor protein(amyloid precursor protein,APP)expression is related to the K670N/M671L(Swedish),1716V(Florida),and V7171(London)mutations,and presenilin 1(PSI)is affected by the M146L and L286V mutations.5 × FAD mice express high levels of β-amyloid in the brain at 1.5 months old,and neuritic plaques began to appear at 2 months old.The pathological phenotypes of 5 × FAD mice include amyloid plaque aggregation,neuronal loss,gliosis,and memory dysfunction,while their biological characteristics include changes in the formation of brain β-amyloid plaques,hyperphosphorylation of Tau protein,synaptic dysfunction,neuroinflammatory response,mitochondrial dysfunction,blood-brain barrier injury,neuronal injury,endoplasmic reticulum stress,and eye lesions.As a classic animal model of AD,5 × FAD transgenic mice can simulate the neuropathological process and behavioral manifestations of late-stage AD in humans,and these mice are thus widely used in research into the pathogenesis of AD and the development of new drugs.In this review,we summarize the model construction,biological background,and biological characteristics of 5 x FAD transgenic mice,and the development and application of drugs for the prevention and treatment of AD,to provide references for the application of 5 x FAD transgenic transgenic mice in AD research.
