Research progress on animal models for the evaluation of diarrhea-predominant irritable bowel syndrome

VernacularTitle:腹泻型肠易激综合征动物模型评价的研究进展
Author: Jiahe ZHANG ¹ ; Wang ZHU ; Danting SHEN ; Xiling YANG ; Fengbin LIU ; Qiuke HOU
Author Information

1. 广州中医药大学第一临床医学院,广州 510405
Keywords: diarrhea-predominant irritable bowel syndrome(IBS-D); animal model; evaluation method
From: Acta Laboratorium Animalis Scientia Sinica 2024;32(2):238-247
CountryChina
Language:Chinese
Abstract: Irritable bowel syndrome(IBS)is one of the most common functional gastrointestinal disorders,of which diarrhea-predominant IBS(IBS-D)accounts for the largest proportion.The pathogenesis of IBS-D is complicated and diverse,and there is currently a lack of clinically effective drugs.The establishment of animal models is an essential tool for further studies of the disease mechanisms,evaluation of clinical efficacy,and drug development,and the preparation and evaluation standards of models are important factors affecting the quality of the research.Based on the currently accepted pathogenesis of IBS-D and the previous modeling experience of our research group,this review systematically summarizes the evaluation method used in animal models of IBS-D in terms of diarrhea observation,visceral sensitivity tests,and intestinal motility tests,to provide a reference for future studies.