Progress in depression research using genetically modified animal models
10.3969/j.issn.1005-4847.2023.12.012
- VernacularTitle:应用基因修饰动物模型研究抑郁症进展
- Author:
Mengyao LI
1
;
Feng GAO
;
Fanfan ZHENG
;
Mengze HE
;
Zhao HE
;
Youlei LI
Author Information
1. 延安大学医学院,陕西 延安 716000
- Keywords:
depression;
gene knockout;
monoamine system;
brain-derived neurotrophic factor(BDNF);
glutamic acid;
HPA axis
- From:
Acta Laboratorium Animalis Scientia Sinica
2023;31(12):1610-1616
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a complex mental disease with polygenic inheritance and a high incidence.Our understanding of the clinical manifestations and pathogenesis of depression has recently improved.Continuous progress in gene-editing technologies has increased the construction efficiency and reduced the cost of gene-knockout animals,leading to their increasing use in the fields of basic research and drug development for depression and providing a powerful tool for revealing the pathogenesis of depression.In this review,we summarize recent progress in understanding the roles and mechanisms of candidate genes in depression using knockout model mice.
