Application of NK cells and their immunotherapy in tumor immunotherapy
10.3969/j.issn.1005-4847.2023.11.012
- VernacularTitle:NK细胞及其免疫疗法在肿瘤免疫治疗中的应用
- Author:
Saifei WANG
1
;
Jing XUN
;
Xueliang WU
;
Hui ZHANG
;
Qi ZHANG
;
Dapeng ZHANG
Author Information
1. 天津大学医学工程与转化医学研究院,天津 300072
- Keywords:
natural killer cells;
immunotherapy;
tumor immunity;
clinical treatment
- From:
Acta Laboratorium Animalis Scientia Sinica
2023;31(11):1479-1484
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer(NK)cells as intrinsic immune cells kill tumor cells without the need for pre-stimulation by tumor antigens.Therefore,NK cell based immunotherapy has unique advantages and has made significant progress in tumor treatment.In this article,we review the development,classification,and mechanism of NK cells as well as the applications of NK cell based immunotherapies,including immune checkpoint inhibitors,adoptive cell therapy,and NK cell adapters in tumor immunity.Thus,we elucidate the principle,current status,and developmental trend of NK cell-based anti-tumor immunotherapies to provide ideas for their development and application in the field of tumor immunotherapy.
